Search results for "Non Alcoholic Fatty Liver Disease"

showing 3 items of 3 documents

Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid Inflammation.

2015

Nonalcoholic fatty liver disease (NAFLD) is defined by excessive triglycerides (TGs) accumulation in the liver (>5% of hepatocytes histologically) in the absence of alcohol excess. The NAFLD ranges from simple steatosis to steatohepatitis and cirrhosis. The NAFLD and nonalcoholic steatohepatitis (NASH) are now the number one cause of liver disease in Western countries. The prevalence of NAFLD is increasing but is underreported, and the epidemiology and demographic characteristics vary worldwide. The prevalence is increasing because of the rising occurrence of obesity and type 2 diabetes (T2DM); in fact, NAFLD is considered as the hepatic manifestation of metabolic syndrome (MetS). Nonalcoho…

Carotid Artery Diseasesmedicine.medical_specialtyVery low-density lipoproteinLipoproteins//purl.org/becyt/ford/3.3 [https]Risk FactorsInternal medicineNonalcoholic fatty liver diseasemedicinePrevalenceHumansInflammationAdiponectinbusiness.industryFatty liverNon Alcoholic Fatty Liver Diseasenutritional and metabolic diseasesmedicine.diseasedigestive system diseasesFatty LiverOxidative StressEndocrinologyCardiovascular DiseasesDisease Progression//purl.org/becyt/ford/3 [https]Hepatic lipaseMetabolic syndromeSteatohepatitisInsulin ResistanceCardiology and Cardiovascular MedicinebusinessBiomarkersLipoproteinAngiology
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EPIGENETIC PROFILING AND THERAPEUTICS IN LIVER DISEASE

2019

Settore BIO/13 - Biologia ApplicataEpigenetic Liver Disease Non Alcoholic Fatty Liver DiseaseSettore MED/49 - Scienze Tecniche Dietetiche Applicate
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Copper/MYC/CTR1 interplay: A dangerous relationship in hepatocellular carcinoma

2018

Free serum copper correlates with tumor incidence and progression of human cancers, including hepatocellular carcinoma (HCC). Copper extracellular uptake is provided by the transporter CTR1, whose expression is regulated to avoid excessive intracellular copper entry. Inadequate copper serum concentration is involved in the pathogenesis of Non Alcoholic Fatty Liver Disease (NAFLD), which is becoming a major cause of liver damage progression and HCC incidence. Finally, MYC is over-expressed in most of HCCs and is a critical regulator of cellular growth, tumor invasion and metastasis. The purpose of our study was to understand if higher serum copper concentrations might be involved in the prog…

0301 basic medicineCirrhosisCopper; CTR1; Hepatocellular carcinoma; MYC; Non alcoholic fatty liver disease; OncologyMYCMetastasis03 medical and health sciencesmedicineOncogeneCell growthChemistryFatty liverCTR1hepatocellular carcinomaHCCSmedicine.diseasedigestive system diseases3. Good health030104 developmental biologyOncologyHepatocellular carcinomacopperCancer researchCTR1; MYC; copper; hepatocellular carcinoma; non alcoholic fatty liver diseaseLiver cancerResearch Papernon alcoholic fatty liver disease
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